Alpha 1 Antitrypsin in Pathogenesis of Hepatocellular Carcinoma
نویسندگان
چکیده
منابع مشابه
alpha-۱-antitrypsin in pathogenesis of hepatocellular carcinoma
context alpha-1-antitrypsin (a1at) is the most abundant liver-derived, highly polymorphic, glycoprotein in plasma. hereditary deficiency of alpha-1-antitrypsin in plasma (a1atd) is a consequence of accumulation of polymers of a1at mutants in endoplasmic reticulum of hepatocytes and other a1at-producing cells. one of the clinical manifestations of a1atd is liver disease in childhood and cirrhosi...
متن کاملAlpha-1-Antitrypsin in Pathogenesis of Hepatocellular Carcinoma
CONTEXT Alpha-1-antitrypsin (A1AT) is the most abundant liver-derived, highly polymorphic, glycoprotein in plasma. Hereditary deficiency of alpha-1-antitrypsin in plasma (A1ATD) is a consequence of accumulation of polymers of A1AT mutants in endoplasmic reticulum of hepatocytes and other A1AT-producing cells. One of the clinical manifestations of A1ATD is liver disease in childhood and cirrhosi...
متن کاملAlpha-1-antitrypsin deficiency and hepatocellular carcinoma.
Forty-two cases of hepatocellular carcinoma (HCC) were examined for the presence of the inclusions of alpha-1-antitrypsin (AAT), which indicate a carrier state for the Pi Z gene. These were found in the non-neoplastic liver tissue of two cases of HCC and in one of the 98 control livers, a difference that is not statistically significant. Typical globules of AAT deficiency were not found in HCC ...
متن کاملAlpha-i -antitrypsin deficiency and hepatocellular carcinoma
It has been established that alpha-1-antitrypsin (AAT) deficiency due to the homozygous Pi Z state may give rise to cirrhosis and hepatic fibrosis, although the mechanism whereby this occurs is obscure. Also there are numerous reports of hepatocellular carcinoma (HCC) developing in such cases (Ganrot et al., 1967; Berg and Eriksson, 1972; Eriksson and Hagerstrand, 1974). The position of the het...
متن کاملMolecular mechanism of hepatocellular injury in alpha 1 antitrypsin deficiency.
could have been generated during the chloroform-phe-no1 extraction because the internal standard was not added until after the enzymatic hydrolysis and the use of phenol for DNA extraction has been associated with artefactual generation of 8-hydroxy-2'-deoxyguano-sine. Furthermore, some readers might object to the use of ascorbic acid as an antioxidant because iron-ascorbate system s have often...
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ژورنال
عنوان ژورنال: Hepatitis Monthly
سال: 2012
ISSN: 1735-143X,1735-3408
DOI: 10.5812/hepatmon.7042